Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer’s disease
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منابع مشابه
Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer's disease.
Platelets release glutamate upon activation and are an important clearance system of the amino acid from blood, through high-affinity glutamate uptake, similar to that described in brain synaptosomes. Since platelet glutamate uptake is decreased in neurodegenerative disorders, we performed a morphological and molecular characterization of platelet glutamate transporters. The three major brain g...
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Glutamate transporters in neurologic disease.
The neurotoxic properties of glutamate were first demonstrated in 1957 by Lucas and Newhouse, who showed that systemic administration of glutamate to infant mice caused retinal degeneration. Over the last 4 decades, a direct correlation between the neuroexcitatory and neurotoxic properties of glutamate has been linked to activation of excitatory amino acid receptors. This overactivation leads t...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2004
ISSN: 0197-4580
DOI: 10.1016/s0197-4580(03)00085-x